中文   |  English

Related News

ProductsDetails

Retapamulin
Product Name:

Retapamulin

CAS No.:
224452-66-8
Online Order:
Message

Product Introduction

Retapamulin(cas 224452-66-8) is a topical antibiotic developed by GlaxoSmithKline. high quality and best price Retapamulin(cas 224452-66-8) Chinese supplier(manufacturers) think that It is the first drug in the new class of pleuromutilin antibiotics to be approved for human use. It is marketed as an ointment under the brand names Altabax and Altargo.
Retapamulin(cas 224452-66-8) was approved by the United States Food and Drug Administration in April 2007 for the treatment of bacterial skin infections such as impetigo. In May 2007, Retapamulin(cas 224452-66-8) received approval in the EU from the European Medicines Agency for the same indication.
Clinical trials have demonstrated its efficacy against certain Gram-positive bacteria including MRSA.

Retapamulin(cas 224452-66-8) Indications
Retapamulin(cas 224452-66-8) is indicated for the topical treatment of impetigo due to Staphylococcus aureus (methicillin-susceptible only) or Streptococcus pyogenes.

Retapamulin(cas 224452-66-8) Pharmacology
Mechanism of action
Retapamulin(cas 224452-66-8) is an antibacterial agent, specifically a protein synthesis inhibitor. The medication selectively inhibits bacterial protein synthesis by interacting at a site on the 50S subunit of the bacterial ribosome through an interaction that differs from other antibiotics.

Retapamulin(cas 224452-66-8) Pharmakinetics
Systemic exposure following topical application through intact skin is low.

Retapamulin(cas 224452-66-8) Contraindications
None yet reported.

Adverse reactions
The most common reported adverse reaction was irritation at the application site.

high quality and best price Retapamulin(cas 224452-66-8) Chinese supplier(manufacturers) think that The Retapamulin, with the CAS registry number 224452-66-8, is also known as Acetic acid, 2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester. This chemical's molecular formula is C30H47NO4S and molecular weight is 516.76. What's more, its systematic name is (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propano-3aH-cyclopenta[8]annulen-8-yl{[(1R,3s,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]sulfanyl}acetate. Its classification codes is Topical antibiotic for secondarily infected traumatic lesions (SITL) and secondarily infected dermatoses (SID) or impetigo. This chemical is approved by the United States Food and Drug Administration in April 2007 for the treatment of bacterial skin infections such as impetigo. In May 2007, it received approval in the EU from the European Medicines Agency for the same indication. It is a synthetic pleuromutilin.
Physical properties of Retapamulin(cas 224452-66-8) are:
(1)ACD/LogP: 5.006;
(2)# of Rule of 5 Violations: 2;
(3)ACD/LogD (pH 5.5): 2.50;
(4)ACD/LogD (pH 7.4): 2.51;
(5)ACD/BCF (pH 5.5): 11.79;
(6)ACD/BCF (pH 7.4): 11.87;
(7)ACD/KOC (pH 5.5): 39.54;
(8)ACD/KOC (pH 7.4): 39.82;
(9)#H bond acceptors: 5;
(10)#H bond donors: 2;
(11)#Freely Rotating Bonds: 6;
(12)Polar Surface Area: 105.97 ?2;
(13)Flash Point: 331.042 °C;
(14)Enthalpy of Vaporization: 105.899 kJ/mol;
(15)Boiling Point: 623.766 °C at 760 mmHg;
(16)Vapour Pressure: 0 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: CN5[C@H]1CC[C@@H]5C[C@@H](C1)SC(C([O-])=O)[C@@H]4C[C@@](C)(C=C)[C@@H](O)[C@H](C)[C@@]32CCC(=O)[C@H]2[C@@]4(C)[C@H](C)CC3
(2)Std. InChI: InChI=1S/C30H47NO4S/c1-7-28(4)16-22(24(27(34)35)36-21-14-19-8-9-20(15-21)31(19)6)29(5)17(2)10-12-30(18(3)26(28)33)13-11-23(32)25(29)30/h7,17-22,24-26,33H,1,8-16H2,2-6H3,(H,34,35)/p-1/t17-,18+,19-,20+,21+,22+,24?,25+,26+,28-,29+,30+/m1/s1
(3)Std. InChIKey: BTPDCEBXECTAID-CLLJVQIRSA-M

Lead biotech (Hangzhou) Co., Ltd is the Retapamulin(cas 224452-66-8),Retapamulin(cas 224452-66-8) manufacturers,high quality and best price Retapamulin(cas 224452-66-8) Chinese supplier,If you need the product price, please contact us